关键词: 胰腺癌, 生物模型, 现状, 展望

Abstract: Attributable to its highly malignant feature, late diagnosis and early metastasis, pancreatic cancer patients often lost the opportunity of radical surgery due to the local advanced lesion. Although significant progress has been made in the effect of comprehensive treatment, the patients were still with poor overall prognosis and low survival rate. The insidious symptoms of pancreatic cancer limited investigators to acquire early tissue timely for in-depth study, therefore, a suitable biological model should be constructed to investigate the molecular mechanisms underlying pancreatic cancer initiation and progression, and to evaluate new therapies. Spontaneous tumor animal models, transplanted tumor models and pancreatic cancer organoid were the most commonly used preclinical biological models, and we reviewed the current trends in applications of biological models in pancreatic cancer in this paper. 

Key words: pancreatic cancer, biological models, current state, future perspectives